| 2024-04-27 16:00 | J45 | Southampton |  | - |  | Stoke City | | h2h |
| 2024-04-16 21:00 | J36 | Southampton | | 3-0 |  | Preston North End | Che Adams 19' 29', Stuart Armstrong 33' | |
| 2024-04-13 16:00 | J43 | Southampton | | 3-2 |  | Watford | Will Smallbone 1', Che Adams 20', Flynn Downes 90'; Ryan Porteous 34', Ismaël Koné 85' | |
| 2024-04-09 20:45 | J42 | Southampton | | 2-1 |  | Coventry City | Kyle Walker-Peters 18', Che Adams 38'; Jake Bidwell 68' | |
| 2024-03-29 16:00 | J39 | Southampton | | 1-1 |  | Middlesbrough | Adam Armstrong 12'; Latte Lath 90' | |
| 2024-03-09 16:00 | J37 | Southampton | | 4-2 |  | Sunderland | Stuart Armstrong 9', Adam Armstrong 37' (P), Joe Rothwell 77' 80'; Romaine Mundle 62', Jobe Bellingham 71' | |
| 2024-02-24 16:00 | J34 | Southampton | | 1-2 |  | Millwall | Che Adams 34'; Japhet Tanganga 5', Zian Flemming 44' (P) | |
| 2024-02-20 20:45 | J29 | Southampton | | 1-2 |  | Hull City | Joe Aribo 88'; Anass Zaroury 11', Fábio Carvalho 36' | |
| 2024-02-10 16:00 | J31 | Southampton | | 5-3 |  | Huddersfield Town | Joe Rothwell 49' 50', Sékou Mara 84', Samuel Edozie 90'; Sorba Thomas 36', David Kasumu 45', Alex Matos 65', Tom Lees 80' (c.s.c.) | |
| 2024-02-06 20:45 | 4T | Southampton | | 3-0 | | Watford | Sékou Mara 52' 58', Che Adams 76' | |
| 2024-01-13 16:00 | J27 | Southampton | | 4-0 |  | Sheffield Wed. | Che Adams 35', Adam Armstrong 63', Ryan Fraser 75', Sékou Mara 85' | |
| 2024-01-06 16:00 | 3T | Southampton | | 4-0 |  | Walsall | Ryan Fraser 6' 68', Sékou Mara 58', Che Adams 78' | |
| 2023-12-29 19:00 | J25 | Southampton | | 2-1 |  | Plymouth Argyle | Carlos Alcaraz 56', Che Adams 63'; Ryan Hardie 90' | |
| 2023-12-26 16:00 | J24 | Southampton | | 5-0 |  | Swansea City | Joe Aribo 17', Samuel Edozie 48', Ryan Fraser 74' 87', Che Adams 90' | |
| 2023-12-16 16:00 | J22 | Southampton | | 4-0 |  | Blackburn Rovers | Samuel Edozie 44', Stuart Armstrong 64', Sékou Mara 90', Carlos Alcaraz 90' | |
| 2023-12-02 16:00 | J19 | Southampton | | 2-0 |  | Cardiff City | Adam Armstrong 11' 15' | |
| 2023-11-29 20:45 | J18 | Southampton | | 1-0 |  | Bristol City | Kyle Walker-Peters 47' | |
| 2023-11-11 16:00 | J16 | Southampton | | 2-1 |  | West Bromwich | Will Smallbone 5', Adam Armstrong 79'; Kyle Bartley 65' | |
| 2023-10-28 13:30 | J14 | Southampton | | 3-1 |  | Birmingham City | Taylor Harwood-Bellis 9', Carlos Alcaraz 22', Adam Armstrong 86'; Jay Stansfield 58' | |
| 2023-10-07 16:00 | J11 | Southampton | | 1-1 |  | Rotherham | Stuart Armstrong 2'; Jordan Hugill 74' | |
| 2023-09-30 13:30 | J9 | Southampton | | 3-1 |  | Leeds United | Adam Armstrong 2' 35', Will Smallbone 31'; Pascal Struijk 58' | |
| 2023-09-19 20:45 | J7 | Southampton | | 0-1 |  | Ipswich Town | Omari Hutchinson 30' | |
| 2023-09-15 21:00 | J6 | Southampton | | 1-4 |  | Leicester City | Samuel Edozie 25'; Jamie Vardy 1', Kasey McAteer 18', Wilfred Ndidi 45', Stephy Mavididi 67' | |
| 2023-08-26 16:00 | J4 | Southampton | | 2-1 |  | QPR | Samuel Edozie 30', Adam Armstrong 64'; Jack Colback 32' | |
| 2023-08-12 16:00 | J2 | Southampton | | 4-4 |  | Norwich City | Jan Bednarek 17', Adam Armstrong 21' (P) 90' (P), Che Adams 57'; Josh Sargent 7', Gabriel Sara 23', Jon Rowe 45', Christian Fassnacht 84' | |
25/04 - 21:00
